3. Study methodology

ID Address Element Name Name in the FReSH form Allowed Data Types Description Display constraints Allowed Values Cardinality Cardinality_End
0 E-061 4.a AnalysisUnit Collection unit Collection unit enumerated Describes the entity being analysed in the study or variable. nan Individual 1 1
1 E-062 4.b ResearchType Study type Study Type enumerated Indicates the type of the research, including interventional (also known as experimental) studies and observational studies. nan Observational Study;Interventional Study 1 1
2 E-153 4.1.a IsClinicalTrial Declaration of a clinical trial Is this a clinical trial? boolean Indicates if the study is a clinical trial. If E-062 = "Interventional study" nan 1 1
3 E-064 4.1.b TrialPhase Study Phase Study Phase array The stage of a clinical trial defining the objectives and methods of evaluating a drug or biological product (tolerance, efficacy, comparison, follow-up). If E-062 = "Interventional study" AND if E-153="True" Phase 1;Phase 2;Phase 3;Phase 4;NA 1 Inf.
ST : For combined phases, check several options.
4 E-063 4.1.c ResearchPurpose Primary research purpose Primary research purpose array The main objective of the intervention(s) being evaluated by the study. If E-062 = "Interventional study" Treatment;Health Services Research;Prevention;Basic Science;Diagnostic;Device Feasability;Supportive Care;Screening;Other 1 Inf.
5 E-178 4.1.d OtherResearchPurpose Other research purpose, details Other research purpose, details string Indicates other research purpose not listed in the provided options. If E-062 = "Interventional study" AND if E-063="Other" nan 0 1
6 E-065 4.1.e InterventionalStudyModel Intervention model Intervention model enumerated General design of the strategy for assigning interventions to participants in a study. If E-062 = "Interventional study" Single Group;Parallel;Crossover;Factorial;Sequential 1 1
7 E-066 4.1.2.a AllocationMode Allocation type Allocation type enumerated Method used to assign participants to different intervention groups or arms in an clinical study. If E-062 = "Interventional study" Randomised;Nonrandomised 1 1
8 E-067 4.1.2.b AllocationUnit Allocation unit Allocation unit enumerated Entity to which the intervention is assigned. If E-062 = "Interventional study" Individuelle;Cluster 1 1
9 E-068 4.1.3.a MaskingType Masking type Masking type enumerated Indicates whether the study is conducted open-label (all parties know the assigned intervention) or with masking (at least one party is unaware of the assigned intervention). If E-062 = "Interventional study" Blinded;Open label 1 1
10 E-069 4.1.3.b BlindedMaskingDetails Blinded masking group(s) Blinded masking group(s) array Specifies which stakeholders in the study (participant, care provider, investigator, outcome assessor ) are unaware of the assigned intervention, in order to reduce bias. If E-062 = "Interventional study" Participant;Care provider;Research Team Member;Outcomes Assessor 1 Inf.
11 E-071 4.1.4.a ArmName Arm name Arm name string Unique title chosen for the arm. If E-062 = "Interventional study" nan 1 1
12 E-072 4.1.4.b ArmType Arm type Arm type enumerated A general description of the study arm. It identifies the role of the intervention that participants receive. Types of arms include experimental arm, active comparator arm, placebo comparator arm, sham comparator arm, and no intervention arm. If E-062 = "Interventional study" Experimental;Active Comparator;Placebo Comparator;Sham Comparator;No intervention;Other 1 1
13 E-073 4.1.4.c ArmTypeOther Other arm type, details Other arm type, details string Indicates any other arm type not listed in the provided options. If E-062 = "Interventional study" AND if E-072 = "Other" nan 0 1
14 E-074 4.1.4.d ArmDescription Arm description Arm description string Brief description of the arm, including its purpose or characteristics. If E-062 = "Interventional study" nan 0 1
15 E-075 4.2.a ObservationalStudyDesign Observational study design Observational study design enumerated Describes the methodological approach of the observational study, specifying how participants are selected and monitored or observed. If E-062 = "Observational study" Cohort study;Case-control study;Practices registry;Morbidity registry;Case study;Case-crossover study;Other 1 1
16 E-076 4.2.b OtherResearchTypeDetails Other study design, details Other study design, details string Indicates any other study design not listed in the provided options. If E-062 = "Observational study" AND if E-075 = "Other" nan 1 1
17 E-154 4.2.c TimePerspective Time perspective Time perspective enumerated Indicates the temporal dimension of data collection in the observational study. If E-062 = "Observational study" Retrospective longitudinal;Prospective longitudinal;One-time cross-sectional study;Repeated cross-sectional study;Other 0 1
18 E-199 4.2.d IsInclusionGroups Declaration of inclusion groups Does the study include several groups defined at enrollment ? boolean Indicates if the study include several groups defined at the time of inclusion. nan nan nan nan
ST : If yes, complete the following fields
19 E-079 4.2.1.a GroupName Group name Group name string Unique title chosen for the inclusion group. nan nan 1 1
20 E-080 4.2.1.b GroupDescription Group description Group description string Description of the characteristics of each group at inclusion, specifying the criteria used to distinguish them (e.g. type of exposure, clinical, socio-demographic or contextual characteristics). nan nan 0 1
21 E-082 4.2.2.a InterventionName Factor/exposure name Factor/exposure name string The specific name of the action, factor or exposure as it is referred to in the study. Factors include various health products or non-invasive approaches, such as education or changes to diet and exercise. Exposures may include, for example, lifestyle habits, environmental factors, or medical history. nan nan 1 1
22 E-083 4.2.2.b InterventionType Factor/exposure type Factor/exposure type enumerated Selection of the category that best describes the factor or the exposure from the predefined list of options. nan Drug;Device;Biological-Vaccine;Procedure-Surgery;Radiation;Behavioral;Genetic;Dietary Supplement;Diagnostic Test;Combination Product;Public Health;Other 0 1
23 E-084 4.2.2.c InterventionTypeOther Other factor/exposure type, details Other factor/exposure type, details string Indicates any other factor or exposure type not listed in the provided options. If E-083="Other" nan 0 1
24 E-115 4.3.a PrimaryOutcomes Primary Outcome Primary Outcome string The main pre-specified measurement or observation of the study, used to address the primary research question. nan nan 1 1
25 E-116 4.3.b SecondaryOutcomes Secondary Outcome(s) Secondary Outcome(s) string Additional pre-specified measurements or observations that provide complementary information or explore related aspects of the primary question. nan nan 0 1